ERCC1 Antibody - middle region (OASG02561)

Catalog No: OASG02561

Size:100 uL

Western Blot using 3T3

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the Internal region of human ERCC1. Location: 110-190aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: ERCC1 Polyclonal Antibody detects endogenous levels of ERCC1 protein.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Target Info

• Gene Symbol: ERCC1
• Gene Full Name: excision repair cross-complementation group 1
• Alias Symbols: UV20, COFS4, RAD10
• NCBI Gene Id: 2067; 13870;
• Description of Target: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
• Uniprot ID: P07992, P07903
• Molecular Weight: 36 kDa