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Catalog No: OPPA00155
Size:5UG
Price: $75.00
SKU
OPPA00155
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ERBB2 Antibody Protein (OPPA00155)

Datasheets/ManualsPrintable datasheet for OPPA00155
Product Info
Predicted Species ReactivityHuman
ClonalityMonoclonal
IsotypeIgG2b.
Additional InformationReconstitution: It is recomended to add 100ul of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which doesn't affect the activity of the ERBB2 antibody. The solution can be clarified by centrifugation.
::Product Introduction: HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.
Reconstitution and StorageThe lyophilized antibody remains stable and fully active when stored at -20C. It is recomended to aliquot the product after reconstitution to avoid repeated freezing/thawing cycles and store frozen at -80C. The Reconstituted antibody can be stored at 4C for a limited period of time; it does not show decline in activity after one week at 4C.
ImmunogenAnti-human ErbB2 mAb, is derived from mice immunized with the recombinant human ErbB2 (43.4 kDa, 397 a.a. and one extra N-terminal Methionin) purified from E. coli.
ConcentrationThe ERBB2 antibody is lyophilized in 0.05M phosphate buffer, 0.1M NaCl, pH 7.2. AZIDE FREE.
Peptide SequenceMTQVCTGTDM KLRLPASPET HLDMLRHLYQ GCQVVQGNLE LTYLPTNASL SFLQDIQEVQ GYVLIAHNQV RQVPLQRLRI TQVCTGTDM KLRLPASPET HLDMLRHLYQ GCQVVQGNLE LTYLPTNASL SFLQDIQEVQ GYVLIAHNQV RQVPLQRLRI VRGTQLFEDN YALAVLDNGD PLNNTTPVTG ASPGGLRELQ LRSLTEILKG GVLIQRNPQL CYQDTILWKD IFHKNNQLAL TLIDTNRSRA CHPCSPMCKG SRCWGESSED CQSLTRTVCA GGCARCKGPL PTDCCHEQCA AGCTGPKHSD CLACLHFNHS GICELHCPAL VTYNTDTFES MPNPEGRYTF GASCVTACPY NYLSTDVGSC TLVCPLHNQE VTAEDGTQRC EKCSKPCARG THSLPPRPAA VPVPLRMQPG PAHPVLSFLR PSWDLVSAFY SLPLAPLSPT SVPISPVSVG RGPDPDAHVA VDLSRYEG.
Application InfoELISA, Western blotting.
Gene SymbolERBB2
Alias SymbolsNEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu
NCBI Gene Id2064
Protein NameReceptor tyrosine-protein kinase erbB-2
Uniprot IDP04626
Protein Accession #NP_001005862.1
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