EPHA5 Antibody (OABF01713)

Catalog No: OABF01713

Size:100ul

Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti EphA5/Eph receptor A5 Polyclonal Antibody, Unconjugated (OABF01713) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed and paraffin-embedded rat brain labeled with Anti-EphA5/Eph receptor A5 Polyclonal Antibody, Unconjugated (OABF01713) 1:200, overnight at 4C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37C.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: WB, IHC-P
• Additional Information: Subcellular location: Extracellular
• Reconstitution and Storage: Store at -20C for 12 months.
• Immunogen: KLH conjugated synthetic peptide derived from human EphA5/Eph receptor A5
• Purification: Purified by Protein A.
• Concentration: 1ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: EPHA5
• Gene Full Name: EPH receptor A5
• Alias Symbols: EK7, CEK7, EHK1, HEK7, EHK-1, TYRO4
• NCBI Gene Id: 2044
• Description of Target: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
• Uniprot ID: P54756