EPAS1 Recombinant Protein (OPCD03875)

Catalog No: OPCD03875

EPAS1 Recombinant Protein (OPCD03875) using SDS-PAGE

EPAS1 Recombinant Protein (OPCD03875) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Cys339-Gln541
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: EPAS1
• Gene Full Name: endothelial PAS domain protein 1
• Alias Symbols: basic-helix-loop-helix-PAS protein MOP2;bHLHe73;class E basic helix-loop-helix protein 73;ECYT4;endothelial PAS domain-containing protein 1;EPAS-1;HIF-1alpha-like factor;HIF-1-alpha-like factor;HIF2A;HIF2-alpha;HIF-2-alpha;HLF;hypoxia-inducible factor 2 alpha;Hypoxia-inducible factor 2-alpha;member of PAS protein 2;MOP2;PAS domain-containing protein 2;PASD2.
• NCBI Gene Id: 2034
• Protein Name: Endothelial PAS domain-containing protein 1
• Description of Target: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
• Uniprot ID: Q99814
• Protein Accession #: NP_001421.2
• Nucleotide Accession #: NM_001430.4
• Protein Size (# AA): Cys339~Gln541
• Molecular Weight: 27kDa