Catalog No: OOMC00025
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OOMC00025
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Entacapone (OOMC00025)

Datasheets/ManualsPrintable datasheet for OOMC00025
Product Info
Product FormatPowder
Additional InformationCAS: 130929-57-6
Molecular Formula: C14H15N3O5
::Chemical Name: (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
::Primary Activity: COMT inhibitor
::COVID-19 Rationale: COMT interacts with SARS-CoV-2 Nsp7
Reconstitution and StorageSoluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml). Store at -20C.
Purity> 98%
Reference1) Forsberg et al. (2003), Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat; J. Pharmacol. Exp. Ther., 304 498 2) Merello et al. (1994), Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson’s disease; J. Neurol. Neurosurg. Psychiatry, 57 186 3) Giovanni et al. (2010), Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta amyloid and protect against amyloid-induced toxicity; J. Biol. Chem., 285 14941 4) Chen et al. (2016), Entacapone is an Antioxident More Potent than Vitamin C and Vitamin E for Scavenging of Hypochlorous Acid and Peroxynitrite, and the Inhibition of Oxidative Stress-induced Cell Death; Med. Sci. Monit., 22 687
Molecular Weight305.29 g/mol
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