Catalog No: OPCD02926
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OPCD02926
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Datasheets/ManualsPrintable datasheet for ENPP1 Recombinant Protein (OPCD02926)
Product Info
Predicted Species ReactivityRat|Rattus norvegicus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Glu568-Ile793
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His and GST Tag
Gene SymbolEnpp1
Gene Full Nameectonucleotide pyrophosphatase/phosphodiesterase 1
Alias Symbolsectonucleotide pyrophosphatase/phosphodiesterase family member 1;E-NPP 1;Npps;Pc1;phosphodiesterase I/nucleotide pyrophosphatase 1;plasma-cell membrane glycoprotein PC-1.
NCBI Gene Id85496
Protein NameEctonucleotide pyrophosphatase/phosphodiesterase family member 1
Description of TargetBy generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
Uniprot IDQ924C3
Protein Accession #NP_445987.1
Nucleotide Accession #NM_053535.1
Protein Size (# AA)Glu568~Ile793
Molecular Weight60kDa
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