Eno1 Antibody - HRP Conjugated (OACA00443)

Catalog No: OACA00443

Size:100ug

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: HRP
• Application: Enzyme-linked immunosorbent assay
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Mouse Growth/differentiation factor 5 protein (376-495AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily.'Storm E.E., Huynh T.V., Copeland N.G., Jenkins N.A., Kingsley D.M., Lee S.-J.Nature 368:639-643(1994)
  [2] Lineage-specific biology revealed by a finished genome assembly of the mouse.'Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009)
  [3] Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.Submitted (JUL-2005)
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: Gdf5
• Gene Full Name: growth differentiation factor 5
• Alias Symbols: b;BMP-14;bone morphogenetic protein 14;bp;brp;cartilage-derived morphogenetic protein-1;CDMP-;Cdmp-1;growth/differentiation factor 5.
• NCBI Gene Id: 14563
• Protein Name: Growth/differentiation factor 5
• Description of Target: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (PubMed:24076600). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity).
• Uniprot ID: P43027