Catalog No: OASE00462 (Formerly GWB-0X0039)
Size:100ug
Price: $439.00
SKU
OASE00462
Availability: Discontinued
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ENaC Gamma Antibody (OASE00462)

Datasheets/ManualsPrintable datasheet for OASE00462
Product Info
Predicted Species ReactivityRat, Mouse, Xenopus, Hamster, Human
Product FormatLiquid. PBS with 50% glycerol and 0.09% sodium azide.
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
ApplicationWB, IHC, ICC, IF
::Certificate of Analysis: 1 ug/mL was sufficient for detection of gamma-ENaC in 20ug of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Reconstitution and StorageStore at -20C. Shipping with Blue Ice or 4C.
ImmunogenProduced against the C-terminal tail (amino acids 629-650) of rat gamma ENaC (antibody designation L550)
PurificationProtein A Purified
Concentration1 mg/ml
SpecificityDetects ~83kDa.
DilutionWB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.
Reference1. Kakizoe Y., et al. (2009) J Hpyertens. 27(8): 1679-1689. 2. Gu Y. (2008) J Cell Physiol. 216(2):453-457.
3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285(4): F600-F609.
4. Mauro T., et al. (2002) J Invest Dermatol. 118(4): 589-594.
5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293(3): L537-45.
6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94(1): 120-128.
Storage BufferPBS, 50% glycerol, 0.09% sodium azide
Description The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, α, β, and γ. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
Gene SymbolENaC
Gene Full Namesodium channel, non-voltage-gated 1, gamma subunit
Alias SymbolsSCNN1G, Epithelial Sodium Channel gamma, Amiloride sensitive epithelial sodium channel gamma subunit, Amiloride sensitive sodium channel subunit gamma, Amiloride-sensitive sodium channel subunit gamma, BESC3, ENaC gamma subunit, ENaCG, ENaCgamma, Epithelial Na(+) channel subunit gamma, Epithelial Na+ channel subunit gamma, Gamma ENaC, Gamma NaCH, Gamma-ENaC, Gamma-NaCH, Nonvoltage gated sodium channel 1 subunit gamma, Nonvoltage-gated sodium channel 1 subunit gamma, PHA 1, PHA1, SCNEG, SCNN 1G, SCNN1G, SCNNG_HUMAN, Sodium channel non voltage gated 1 gamma subunit, Sodium channel nonvoltage gated 1 gamma
NCBI Gene Id24768
Description of TargetThe Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2).
ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta, and ?. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
Uniprot IDP37091
Protein Accession #NP_058742
  1. What is the species homology for "ENaC Gamma Antibody (OASE00462)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Rat, Mouse, Xenopus, Hamster, Human".

  2. How long will it take to receive "ENaC Gamma Antibody (OASE00462)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "ENaC Gamma Antibody (OASE00462)" provided in?

    This item is provided in "Liquid. PBS with 50% glycerol and 0.09% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ENaC Gamma Antibody (OASE00462)"?

    This target may also be called "SCNN1G, Epithelial Sodium Channel gamma, Amiloride sensitive epithelial sodium channel gamma subunit, Amiloride sensitive sodium channel subunit gamma, Amiloride-sensitive sodium channel subunit gamma, BESC3, ENaC gamma subunit, ENaCG, ENaCgamma, Epithelial Na(+) channel subunit gamma, Epithelial Na+ channel subunit gamma, Gamma ENaC, Gamma NaCH, Gamma-ENaC, Gamma-NaCH, Nonvoltage gated sodium channel 1 subunit gamma, Nonvoltage-gated sodium channel 1 subunit gamma, PHA 1, PHA1, SCNEG, SCNN 1G, SCNN1G, SCNNG_HUMAN, Sodium channel non voltage gated 1 gamma subunit, Sodium channel nonvoltage gated 1 gamma" in publications.

  5. What is the shipping cost for "ENaC Gamma Antibody (OASE00462)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ENaC Gamma Antibody (OASE00462)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ENaC Gamma Antibody (OASE00462)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ENaC Gamma Antibody (OASE00462)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ENaC"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ENaC"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ENaC"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ENaC"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ENaC"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ENaC"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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