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TRIP13 Antibody - C-terminal region (OAAB08917)

400ul
$320.00
In Stock
Gene Symbol:
TRIP13
NCBI Gene Id:
9319
Protein Name:
Pachytene checkpoint protein 2 homolog
Swissprot Id:
Q15645
Protein Accession #:
NP_004228.1
Alias Symbols:
TRIP13, PCH2, Pachytene checkpoint protein 2 homolog, Human papillomavirus type 16 E1 protein-binding protein, Thyroid hormone receptor interactor 13, Thyroid receptor-interacting protein 13
Replacement Item:
This antibody may replace item sc-107308 from Santa Cruz Biotechnology.
Description of Target:
Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
48551 Da
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB, IHC, FC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TRIP13.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TRIP13.
Species Reactivity:
Human, Mouse, Pig, Rat
Predicted Homology Based on Immunogen Sequence:
Human; Mouse; Pig; Rat
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB08917
Sample Type Confirmation:

TRIP13 is strongly supported by BioGPS gene expression data to be expressed in HEK293

Specificity:
This TRIP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 370-400 amino acids from the C-terminal region of human TRIP13.
Isotype:
Ig
Application Info:
WB 1:50 - 100
IHC 1:10 - 50
FC 1:10 - 50
Additional Information:
Precautions: TRIP13 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity)

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