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TP53 Antibody (AMM00023)

100 ul

Regular Price: $249.00

Special Price: $185.00

In Stock
Gene Symbol:
TP53
NCBI Gene Id:
7157
Protein Name:
Cellular tumor antigen p53
Swissprot Id:
P04637
Protein Accession #:
NP_000537
Nucleotide Accession #:
NM_000546
Alias Symbols:
P53, LFS1, TRP53, FLJ92943, TP53
Replacement Item:
This antibody may replace item sc-126 from Santa Cruz Biotechnology.
Description of Target:
Tumor protein p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome
Protein Size (# AA):
393
Molecular Weight:
53kDa
Host:
Mouse
Clonality:
Monoclonal
Application:
CHIP, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TP53.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TP53.
Species Reactivity:
Human
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-TP53 (AMM00023) antibody
Sample Type Confirmation:

TP53 is strongly supported by BioGPS gene expression data to be expressed in DU145

Isotype:
Mouse IgG
Target Reference:
Khanna,K.K., et al., Nat. Genet. 20 (4), 398-400 (1998)

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