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SP1 Antibody - C-terminal region (Phospho-P692) (OAAB07695)

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400ul
$320.00
In Stock
Gene Symbol:
SP1
NCBI Gene Id:
6667
Protein Name:
Transcription factor Sp1
Swissprot Id:
P08047
Protein Accession #:
NP_001238754.1
Alias Symbols:
SP1, TSFP1, Transcription factor Sp1
Replacement Item:
This antibody may replace item sc-14027 from Santa Cruz Biotechnology.
Description of Target:
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
80693 Da
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB, IHC, FC, IF
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SP1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SP1.
Species Reactivity:
Human, Mouse, Rat
Predicted Homology Based on Immunogen Sequence:
Human; Mouse; Rat
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets / Downloads:
OAAB07695
Specificity:
This SP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 684-715 amino acids from the C-terminal region of human SP1.
Isotype:
Ig
Application Info:
WB 1:100 - 500
IHC 1:50 - 100
FC 1:10 - 50
IF 1:10 - 50
Additional Information:
Precautions: SP1 Antibody (C-term P692) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression
:::
Cellular Location: Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location
Tissue Location: Up-regulated in adenocarcinomas of the stomach (at protein level)
Protocol:
Tips Information:

Product Protocol: SP1 antibody tested with human K562 by western blot (OAAB07695)

Please find the protocol used to generate the western blot data for item (OAAB07695) by going here

Product datasheet link: SP1 antibody (OAAB07695)

SP1 Antibody (C-term P692) (Cat. #OAAB07695) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SP1 antibody detected the SP1 protein (arrow).

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology's SP1 antibody (OAAB07695) has been tested using other cell lysates and tissues. To obtain more data about this antibody, please email us at info@avivasysbio.com

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva's products are guaranteed for the applications and experimental sample types mentioned. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

Product Protocol: SP1 antibody tested with human colon carcinoma in immunohistochemistry (IHC) (OAAB07695)

Please go here to see the protocol used for Aviva's SP1 antibody (OAAB07695)

Product datasheet can be found here: SP1 antibody (OAAB07695)

IHC information:
SP1 Antibody (C-term P692) (Cat. #OAAB07695) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SP1 Antibody (C-term P692) for immunohistochemistry. Clinical relevance has not been evaluated.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology's SP1 antibody (OAAB07695) has been tested using other cell lysates and tissues. To obtain more data about this antibody, please email us at info@avivasysbio.com

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva's products are guaranteed for the applications and experimental sample types mentioned. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

 
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