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SOX18 antibody - middle region (ARP33056_P050)

100 ul

Regular Price: $289.00

Special Price: $215.00

In Stock

Conjugation Options

ARP33056_P050-FITC Conjugated

ARP33056_P050-HRP Conjugated

ARP33056_P050-Biotin Conjugated

Gene Symbol:
SOX18
NCBI Gene Id:
54345
Official Gene Full Name:
SRY (sex determining region Y)-box 18
Protein Name:
Transcription factor SOX-18
Swissprot Id:
P35713
Protein Accession #:
NP_060889
Nucleotide Accession #:
NM_018419
Alias Symbols:
HLTS
Replacement Item:
This antibody may replace item sc-166025 from Santa Cruz Biotechnology.
Description of Target:
SOX18 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.
Protein Size (# AA):
384
Molecular Weight:
41kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IF, WB, IHC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SOX18.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SOX18.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human SOX18
Species Reactivity:
Cow, Guinea Pig, Human, Mouse, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 86%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Complete computational species homology data:
Anti-SOX18 (ARP33056_P050)
Peptide Sequence:
Synthetic peptide located within the following region: RTAPPAAPLAGLYYGTLGTPGPYPGPLSPPPEAPPLESAEPLGPAADLWA
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
GKAP1; MECP2; MEF2C; HMGB1;
Blocking Peptide:
For anti-SOX18 (ARP33056_P050) antibody is Catalog # AAP33056 (Previous Catalog # AAPP04085)
Datasheets/Manuals:
Printable datasheet for anti-SOX18 (ARP33056_P050) antibody
Target Reference:
Spataro,V., et al., (2005) Arterioscler. Thromb. Vasc. Biol. 25 (11), 2398-2403
Publications:

Duong, T. et al. Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice. Cancer Res. 72, 3105-14 (2012). IF, WB, IHC, Cow, Guinea Pig, Human, Mouse, Rat 22523034

Deng, Y., Atri, D., Eichmann, A. & Simons, M. Endothelial ERK signaling controls lymphatic fate specification. J. Clin. Invest. 123, 1202-15 (2013). IF, WB, IHC, Cow, Guinea Pig, Human, Mouse, Rat 23391722

Park, D.-Y. et al. Lymphatic regulator PROX1 determines Schlemm canal integrity and identity. J. Clin. Invest. 124, 3960-3974 (2014). IF, WB, IHC, Cow, Guinea Pig, Human, Mouse, Rat 25061877

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