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SOCS1 antibody - N-terminal region (ARP42147_T100)

100 ul

Regular Price: $229.00

Special Price: $215.00

In Stock

Conjugation Options

ARP42147_T100-FITC Conjugated

ARP42147_T100-HRP Conjugated

ARP42147_T100-Biotin Conjugated

Gene Symbol:
SOCS1
NCBI Gene Id:
8651
Official Gene Full Name:
Suppressor of cytokine signaling 1
Protein Name:
Suppressor of cytokine signaling 1
Swissprot Id:
O15524
Protein Accession #:
NP_003736
Nucleotide Accession #:
NM_003745
Alias Symbols:
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Replacement Item:
This antibody may replace item sc-7006 from Santa Cruz Biotechnology.
Description of Target:
SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Protein Size (# AA):
211
Molecular Weight:
23kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SOCS1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SOCS1.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human SOCS1
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 92%; Guinea Pig: 93%; Horse: 90%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Complete computational species homology data:
Anti-SOCS1 (ARP42147_T100)
Peptide Sequence:
Synthetic peptide located within the following region: RRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRA
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
CSF2RB; TCEB1; ERBB2; ABL1; CYTIP; gag; TP53; JAK2; ATR; ATM; JAK1; INSR; FGFR3; LCK; RASA1; PDCD1; IRS1; ETV6; DAB1; TIRAP; VHL; VAV1; TUBG1; RELA; MAP3K5; CLEC7A; PTPN11; TYK2; IRF3; IFNAR1; TCEB2; ALK; COMMD1; TRIM8; PIK3R2; GHR; IRS2; TEC; NCK1; VAV2;
Blocking Peptide:
For anti-SOCS1 (ARP42147_T100) antibody is Catalog # AAP42147 (Previous Catalog # AAPS11808)
Datasheets/Manuals:
Printable datasheet for anti-SOCS1 (ARP42147_T100) antibody
Target Reference:
Melzner,I., (2006) Int. J. Cancer 118 (8), 1941-1944

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