Now Offering Over 102,157 Antibodies & 44,722 Antigens!

ROCK1 Antibody - middle region (OASG06458)

Print Page
100 uL
$215.00
In Stock
Gene Symbol:
ROCK1
NCBI Gene Id:
6093; 19877; 81762
Official Gene Full Name:
Rho-associated, coiled-coil containing protein kinase 1
Swissprot Id:
Q13464, P70335, Q63644
Alias Symbols:
ROCK1, Rho-associated protein kinase 1, Renal carcinoma antigen NY-REN-35, Rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, ROCK-I, p160 ROCK-1, p160ROCK
Replacement Item:
This antibody may replace item sc-17794 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
Molecular Weight:
160 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Application:
WB, IHC, ELISA
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ROCK1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ROCK1.
Immunogen:
Synthesized peptide derived from the Internal region of human Rock-1.
Species Reactivity:
Human, Mouse, Rat, Monkey
Product Format:
Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Concentration:
1 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-ROCK1 (OASG06458) antibody
Specificity:
Rock-1 Polyclonal Antibody detects endogenous levels of Rock-1 protein.
Isotype:
IgG
Application Info:
WB 1:500-1:2000; IHC 1:100-1:300; Immunocytochemistry 1:200-1:1000; ELISA 1:20000;
Protocol:
Tips Information:
 
X
Ask a Question

Tell us what you think about this item!

Write A Review
    Please, wait...