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Now Offering Over 102,157 Antibodies & 44,722 Antigens!

Wnt Signaling

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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    RAC2 Antibody (OASA06415)

    RAC2 Antibody (OASA06415)

    Protein Name:Ras-related C3 botulinum toxin substrate 2
    Catalog #:OASA06415
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $560.00
  •  
    CCND1 Antibody (OASA00562)

    CCND1 Antibody (OASA00562)

    Protein Name:G1/S-specific cyclin-D1
    Catalog #:OASA00562
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, FC, IP, IHC-FFPE, WB
    Product Size: 0.1mg
    Price (USD): $490.00
  •  
    PKA CATALYTIC SUBUNIT Antibody (OASA00361)

    PKA CATALYTIC SUBUNIT Antibody (OASA00361)

    Protein Name:cAMP-dependent protein kinase catalytic subunit alpha
    Catalog #:OASA00361
    Type: mAb
    Reacts with:
    Application: ELISA
    Product Size: 0.2mg
    Price (USD): $360.00
  •  
    CTNNB1 Antibody (OASA07131)

    CTNNB1 Antibody (OASA07131)

    Protein Name:Catenin beta-1
    Catalog #:OASA07131
    Type: pAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, WB, IP, IHC-FFPE
    Product Size: 50ul
    Price (USD): $835.00
  •  
    FZD4 Antibody (OASA06098)

    FZD4 Antibody (OASA06098)

    Protein Name:Frizzled-4
    Catalog #:OASA06098
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $530.00
  •  
    CREBBP Antibody (OASA07643)

    CREBBP Antibody (OASA07643)

    Protein Name:CREB-binding protein
    Catalog #:OASA07643
    Type: pAb
    Reacts with: Human
    Application: IP, WB
    Product Size: 0.1mg
    Price (USD): $640.00

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