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Cell Cycle

The cell cycle pathway is a unidirectional process that governs cell division. This process, which cannot be reversed once started, is critical for cell survival. The cell cycle typically involves four phases: S phase, in which DNA is replicated, M phase, in which chromosomes are separated and two distinct cells are formed, and G1 and G2 phases during which the cell is preparing for cell division. The majority of the cell cycle pathway is regulated by two classes of proteins: cyclin-dependent kinases (CDKs) and cyclins. Cyclins and CDKs form complexes that enable CDKs to phosphorylate and activate specific cell cycle intermediates. In the initial stages of the cell-cycle signal, cyclin D will bind to CDK4 and this complex will phosphorylate the retinoblastoma (Rb) gene[1]. During a quiescent state, Rb is bound to DNA and blocks the transcription of specific genes. After phosphorylation, Rb becomes unbound and genes necessary for the cell cycle are now accessible.

The cell cycle pathway is a highly-regulated process that incorporates three major checkpoints. The first checkpoint is the G1 checkpoint, which determines whether or not a cell will enter into the cell division process. The second checkpoint, G2, will determine if the cell will enter into mitosis. Both the G1 and G2 checkpoints can be affected by the presence or absence of various growth factors, DNA damage, or replicative senescence. The final checkpoint, metaphase, ensures proper chromosome alignment prior to cell division. The cell cycle pathway is intrinsically linked to cell survival and cell death. For instance, failure of a cell to meet the requirements of the individual cell cycle checkpoints will result in the cell undergoing apoptosis.

In cancer, the cell cycle checkpoints are often dysfunctional. Checkpoint proteins, such as Rb or p53, are often mutated or inactivated and this can result in cell division despite incomplete DNA synthesis and segregation errors. Inappropriate continuation of the cell cycle can lead to genomic instability, which is a common feature of malignant cells.

1. Nigg. 1995. Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays. 17(6):471-80.

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Cell Cycle pathway image by Aviva Systems Biology

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    EP300 Antibody (OASA08061)

    EP300 Antibody (OASA08061)

    Protein Name:Histone acetyltransferase p300
    Catalog #:OASA08061
    Type: pAb
    Reacts with: Human
    Application: IP, WB
    Product Size: 0.1mg
    Price (USD): $640.00
  •  
    CDK7 Antibody (OASA02603)

    CDK7 Antibody (OASA02603)

    Protein Name:Cyclin-dependent kinase 7
    Catalog #:OASA02603
    Type: mAb
    Reacts with: Human
    Application: IHC-F, IP, WB
    Product Size: 0.1mg
    Price (USD): $680.00
  •  
    SMC3 Antibody (OASA08795)

    SMC3 Antibody (OASA08795)

    Protein Name:Structural maintenance of chromosomes protein 3
    Catalog #:OASA08795
    Type: pAb
    Reacts with: Cow, Human, Mouse
    Application: IP, WB
    Product Size: 50ug
    Price (USD): $395.00
  •  
    TGFB1 Antibody (OASA04458)

    TGFB1 Antibody (OASA04458)

    Protein Name:Transforming growth factor beta-1
    Catalog #:OASA04458
    Type: mAb
    Reacts with: Cow, Human, Mouse
    Application: ELISA, IHC-FFPE, WB
    Product Size: 0.1mg
    Price (USD): $590.00
  •  
    Ywhab Antibody (OASA06929)

    Ywhab Antibody (OASA06929)

    Protein Name:14-3-3 protein beta/alpha
    Catalog #:OASA06929
    Type: pAb
    Reacts with: Rat
    Application: WB
    Product Size: 0.1ml
    Price (USD): $750.00
  •  
    CDC16 Antibody (OASA07610)

    CDC16 Antibody (OASA07610)

    Protein Name:Cell division cycle protein 16 homolog
    Catalog #:OASA07610
    Type: pAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE, WB
    Product Size: 50ug
    Price (USD): $750.00
  •  
    MAD2L1 Antibody (OASA08336)

    MAD2L1 Antibody (OASA08336)

    Protein Name:Mitotic spindle assembly checkpoint protein MAD2A
    Catalog #:OASA08336
    Type: pAb
    Reacts with: Human
    Application: ELISA, IF, IHC-FFPE, WB
    Product Size: 50ug
    Price (USD): $675.00
  •  
    CDC25A Antibody (OASA02601)

    CDC25A Antibody (OASA02601)

    Protein Name:M-phase inducer phosphatase 1
    Catalog #:OASA02601
    Type: mAb
    Reacts with: Human
    Application: IP, WB
    Product Size: 0.1mg
    Price (USD): $710.00
  •  
    CDKN2B Antibody (OASA03182)

    CDKN2B Antibody (OASA03182)

    Protein Name:Cyclin-dependent kinase 4 inhibitor B
    Catalog #:OASA03182
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, IP, WB
    Product Size: 0.1mg
    Price (USD): $590.00

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