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PML antibody - N-terminal region (ARP38184_P050)

100 ul

Regular Price: $289.00

Special Price: $215.00

In Stock

Conjugation Options

ARP38184_P050-FITC Conjugated

ARP38184_P050-HRP Conjugated

ARP38184_P050-Biotin Conjugated

Gene Symbol:
PML
NCBI Gene Id:
5371
Official Gene Full Name:
Promyelocytic leukemia
Protein Name:
Protein PML
Swissprot Id:
P29590
Protein Accession #:
NP_150250
Nucleotide Accession #:
NM_033247
Alias Symbols:
MYL, PP8675, RNF71, TRIM19
Replacement Item:
This antibody may replace item sc-18423 from Santa Cruz Biotechnology.
Description of Target:
PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein Size (# AA):
435
Molecular Weight:
48kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PML.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PML.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human PML
Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human: 100%
Complete computational species homology data:
Anti-PML (ARP38184_P050)
Peptide Sequence:
Synthetic peptide located within the following region: PSPSPSPTERAPASEEEFQFLRCQQCQAEAKCPKLLPCLHTLCSGCLEAS
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
RPL11; RPL5; SUMO1; UBC; TP53; SUMO2; SUMO3; MDM2; RNF4; EGFR; NCOA2; SP100; DAXX; MAPK7; HDAC1; ATXN1; ATRX; ASF1A; EHMT2; HIRA; HTT; H3F3A; ATF7IP; PML; JAK1; EIF4E; GLIS2; UBE2I; smt3; HDAC11; HDAC6; LMNA; RNF111; CDK6; CDK2; CDK1; CASP8AP2; RBX1; SH3G
Blocking Peptide:
For anti-PML (ARP38184_P050) antibody is Catalog # AAP38184 (Previous Catalog # AAPP20360)
Datasheets/Manuals:
Printable datasheet for anti-PML (ARP38184_P050) antibody
Specificity:
isoform 1-14 specific
Target Reference:
Eun,B., (2008) J. Biol. Chem. 283 (9), 5939-5949

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