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PHF6 antibody - N-terminal region (ARP51237_T100)

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100 ul

Regular Price: $229.00

Special Price: $215.00

In Stock

Conjugation Options

ARP51237_T100-FITC Conjugated

ARP51237_T100-HRP Conjugated

ARP51237_T100-Biotin Conjugated

Gene Symbol:
PHF6
NCBI Gene Id:
84295
Official Gene Full Name:
PHD finger protein 6
Protein Name:
PHD finger protein 6
Swissprot Id:
Q8IWS0
Protein Accession #:
NP_115834
Nucleotide Accession #:
NM_032458
Alias Symbols:
BORJ, MGC14797, BFLS, CENP-31
Replacement Item:
This antibody may replace item sc-131747 from Santa Cruz Biotechnology.
Description of Target:
PHF6 is a member of the plant homeodomain (PHD)-like finger (PHF) family. PHF6 is a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation that localizes to the nucleolus. Mutations affecting the coding region of its gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears.This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Protein Size (# AA):
365
Molecular Weight:
41kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PHF6.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PHF6.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human PHF6
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Dog: 100%; Guinea Pig: 92%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 100%
Complete computational species homology data:
Anti-PHF6 (ARP51237_T100)
Peptide Sequence:
Synthetic peptide located within the following region: VGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFH
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; SUMO1; NEDD8; BMI1; HECW2; CAND1; CUL3; HDGF;
Blocking Peptide:
For anti-PHF6 (ARP51237_T100) antibody is Catalog # AAP51237 (Previous Catalog # AAPP28308)
Datasheets/Manuals:
Printable datasheet for anti-PHF6 (ARP51237_T100) antibody
Target Reference:
Vallee,D., (2004) J. Med. Genet. 41 (10), 778-783
 
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