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PECAM1 Antibody (OAAB21748)

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100 ul
$320.00
In Stock
Gene Symbol:
PECAM1
NCBI Gene Id:
5175
Official Gene Full Name:
platelet/endothelial cell adhesion molecule 1
Swissprot Id:
P16284
Protein Accession #:
NP_000433.4
Nucleotide Accession #:
NM_000442.4
Alias Symbols:
CD31, PECA1, GPIIA', PECAM-1, endoCAM, CD31/EndoCAM
Replacement Item:
This antibody may replace item sc-101454 from Santa Cruz Biotechnology.
Description of Target:
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
Molecular Weight:
83 kDa
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB, IF, IHC-P
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PECAM1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PECAM1.
Species Reactivity:
Human, Mouse
Predicted Homology Based on Immunogen Sequence:
Human, Mouse
Product Format:
Liquid
Reconstitution and Storage:
Store at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets / Downloads:
Printable datasheet for anti-PECAM1 (OAAB21748) antibody
Preservative:
0.03% Proclin300 and 50% glycerol
Formulation:
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Additional Information:
Function: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-69 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
Protocol:
Tips Information:
 
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