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PAF1 Antibody (OACA05636)

100 ug
    $290.00
    In Stock
    Gene Symbol:
    PAF1
    NCBI Gene Id:
    54623
    Official Gene Full Name:
    PAF1 homolog, Paf1/RNA polymerase II complex component
    Protein Name:
    RNA polymerase II-associated factor 1 homolog
    Swissprot Id:
    Q8N7H5
    Protein Accession #:
    NP_001243755
    Nucleotide Accession #:
    NM_001256826
    Alias Symbols:
    F23149_1, FLJ11123, hPAF1, Pancreatic differentiation protein 2, PD2, RNA polymerase II-associated factor 1 homolog
    Description of Target:
    Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro.
    Host:
    Rabbit
    Clonality:
    Polyclonal
    Purification:
    Protein G purified
    Application:
    ELISA, WB, IHC
    Tissue Tool:
    Find tissues and cell lines supported by DNA array analysis to express PAF1.
    RNA Seq:
    Find tissues and cell lines supported by RNA-seq analysis to express PAF1.
    Immunogen:
    Recombinant human RNA polymerase II-associated factor 1 homolog protein (1-300AA)
    Species Reactivity:
    Human, Mouse
    Product Format:
    Liquid
    Reconstitution and Storage:
    Shipped at 4C. Upon delivery aliquot and store at -20C or -80C. Avoid repeated freeze.
    Datasheets/Manuals:
    Printable datasheet for anti-PAF1 (OACA05636) antibody
    Preservative:
    0.03% Proclin 300
    Formulation:
    50% Glycerol, 0.01M PBS, PH 7.4
    Purity:
    >95%
    Isotype:
    IgG
    Protocol:
    Tips Information:

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