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OUTER CAPSID PROTEIN VP4 Antibody (OACA04413)

100 ug
    $290.00
    In Stock
    Gene Symbol:
    OUTER CAPSID PROTEIN VP4
    Official Gene Full Name:
    Outer capsid protein VP4
    Protein Name:
    Outer capsid protein VP4
    Swissprot Id:
    P11200
    Alias Symbols:
    Hemagglutinin
    Description of Target:
    Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. According to the considered strain, VP4 seems to essentially target sialic acid and/or the integrin heterodimer ITGA2/ITGB1. Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment. VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.
    Host:
    Rabbit
    Clonality:
    Polyclonal
    Purification:
    Caprylic Acid Ammonium Sulfate Precipitation purified
    Application:
    ELISA
    Immunogen:
    Recombinant Rotavirus A Outer capsid protein VP4 protein (247-479AA)
    Product Format:
    Liquid
    Reconstitution and Storage:
    Shipped at 4C. Upon delivery aliquot and store at -20C or -80C. Avoid repeated freeze.
    Datasheets/Manuals:
    Printable datasheet for anti-OUTER CAPSID PROTEIN VP4 (OACA04413) antibody
    Preservative:
    0.03% Proclin 300
    Formulation:
    50% Glycerol, 0.01M PBS, PH 7.4
    Isotype:
    IgG
    Target Reference:
    [1]"Conservation of amino acid sequence of VP8 and cleavage region of 84-kDa outer capsid protein among rotaviruses recovered from asymptomatic neonatal infection." Gorziglia M., Hoshino Y., Buckler-White A., Blumentals I., Glass R., Flores J., Kapikian A.Z., Chanock R.M. Proc. Natl. Acad. Sci. U.S.A. 83:7039-7043(1986). [2]"Group A human rotavirus genomics: evidence that gene constellations are influenced by viral protein interactions." Heiman E.M., McDonald S.M., Barro M., Taraporewala Z.F., Bar-Magen T., Patton J.T. J. Virol. 82:11106-11116(2008). [3]"Identification of two independent neutralization domains on the VP4 trypsin cleavage products VP5* and VP8* of human rotavirus ST3." Padilla-Noriega L., Dunn S.J., Lopez S., Greenberg H.B., Arias C.F. Virology 206:148-154(1995).
    Protocol:
    Tips Information:

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