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NTRK1 Antibody (OABF00092)

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100 ul
$289.00
In Stock

Conjugation Options

OABF00092-FITC Conjugated

OABF00092-HRP Conjugated

OABF00092-Biotin Conjugated

Gene Symbol:
NTRK1
NCBI Gene Id:
4914
Official Gene Full Name:
neurotrophic tyrosine kinase, receptor, type 1
Swissprot Id:
P04629
Alias Symbols:
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA,
Replacement Item:
This antibody may replace item sc-11 from Santa Cruz Biotechnology.
Description of Target:
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Purified by Protein A.
Application:
WB, IHC-P
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express NTRK1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express NTRK1.
Immunogen:
KLH conjugated synthetic peptide derived from human Trk A
Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
Reconstitution and Storage:
Store at -20C for 12 months.
Concentration:
1ug/ul
Datasheets / Downloads:
OABF00092
Conjugation:
Unconjugated
Isotype:
IgG
Application Info:
WB: 1:100 - 1000
IHC-P: : 1:100 - 500
Additional Information:
Subcellular location: Cytoplasm
Protocol:
Tips Information:
 
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