Now Offering Over 102,157 Antibodies & 44,722 Antigens!

NAGS Antibody - middle region (OAAB21501)

200 ul
$320.00
In Stock
Gene Symbol:
NAGS
NCBI Gene Id:
162417
Official Gene Full Name:
N-acetylglutamate synthase
Swissprot Id:
Q8N159
Protein Accession #:
NP_694551.1
Nucleotide Accession #:
NM_153006.2
Alias Symbols:
AGAS, ARGA
Replacement Item:
This antibody may replace item sc-102033 from Santa Cruz Biotechnology.
Description of Target:
The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia.
Molecular Weight:
58 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A column purification, followed by peptide affinity purification
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express NAGS.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express NAGS.
Immunogen:
This NAGS antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 275-309 amino acids from the middle region of human NAGS.
Species Reactivity:
Human, Mouse
Predicted Homology Based on Immunogen Sequence:
Human, Mouse
Product Format:
Liquid
Reconstitution and Storage:
Store at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
500 ug/mL
Datasheets/Manuals:
Printable datasheet for anti-NAGS (OAAB21501) antibody
Preservative:
0.09% Sodium Azide
Formulation:
Purified polyclonal antibody, supplied in PBS with 0.09% sodium azide.
Clone:
RB53229
Isotype:
Rabbit Ig
Additional Information:
Function: Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity.
Target Reference:
Haeberle J.,et al.Hum. Mutat. 21:593-597(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Caldovic L.,et al.Biochem. Biophys. Res. Commun. 299:581-586(2002).
Zhao G.,et al.PLoS ONE 8:E70369-E70369(2013).
Schmidt E.,et al.Biochim. Biophys. Acta 1740:54-59(2005).
Protocol:
Tips Information:

Tell us what you think about this item!

Write A Review
    Please, wait...