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MCM4 Antibody (OAGA03463)

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100 ul
$319.00
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Gene Symbol:
MCM4
NCBI Gene Id:
4173
Official Gene Full Name:
minichromosome maintenance complex component 4
Protein Name:
DNA replication licensing factor MCM4
Swissprot Id:
P33991
Protein Accession #:
NP_005905.2
Nucleotide Accession #:
NM_005914.3
Alias Symbols:
NKCD, CDC21, CDC54, NKGCD, hCdc21, P1-CDC21
Description of Target:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Purified by antigen-affinity chromatography.
Application:
ICC, IF, IHC-P, IP, WB, CHIP
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MCM4.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MCM4.
Immunogen:
Recombinant protein encompassing a sequence within the C-terminus region of human MCM4. The exact sequence is proprietary.
Species Reactivity:
Human, Mouse
Product Format:
Liquid
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Concentration:
1 mg/ml
Datasheets / Downloads:
Printable datasheet for OAGA03463
Preservative:
0.01% Thimerosal
Isotype:
IgG
Application Info:
Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, IP: 1:100-1:500, WB: 1:500-1:10000, ChIP assay. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Storage Buffer:
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Additional Product Images:
Protocol:
Tips Information:
 
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