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MAPK14 Antibody (OAED00105)

100 ug
$285.00
In Stock
Gene Symbol:
MAPK14
NCBI Gene Id:
1432
Official Gene Full Name:
Mitogen-activated protein kinase 14
Protein Name:
Mitogen-activated protein kinase 14
Swissprot Id:
Q16539
Nucleotide Accession #:
NM_001315.2; NM_139012.2; NM_139013.2; NM_139014.2
Replacement Item:
This antibody may replace item sc-114258 from Santa Cruz Biotechnology.
Description of Target:
Six proteins of the p38 subfamily of MAP kinases have been identified to date, including: p38alpha (SAPK2, CSBP) and its splice variant Mxi; p38beta and beta2; p38gamma (ERK6, SAPK3); and p38delta (SAPK4). p38 MAP kinases contain a conserved TGY motif in their activation loop and are activated in response to cytokines, hormones, GPCRs, and osmotic and heat shock to mediate primarily pro-apoptotic and pro-inflammatory responses. MKK3, MKK4, and MKK6 are known to activate p38 family members with varying specificity. All four p38 isoforms are able to phosphorylate the activating transcription factor 2 (ATF2), and differentially activate numerous substrates including Mnk1/2, Msk, phospholipase A2, and the MAPKAP kinase-2 and -3. Activated MAPKAP kinase-2 subsequently phosphorylates the heat shock protein Hsp27, an F-actin binding protein involved in cytoskeletal maintenance.
Host:
Rabbit
Clonality:
Polyclonal
Application:
IHC, IP, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MAPK14.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MAPK14.
Immunogen:
Synthetic peptide corresponding to a portion of human p38. The sequence is completely conserved in mouse.
Species Reactivity:
Human, Mouse, Rat, Bovine, Dog, Chicken, Guinea Pig, Hamster, Monkey, Pig, Rabbit, Sheep
Reconstitution and Storage:
Long Term Storage : -20C
Datasheets/Manuals:
Printable datasheet for anti-MAPK14 (OAED00105) antibody
Specificity:
Recognizes human, mouse, rat, bovine, dog, chicken, guinea pig, hamster, monkey, pig, rabbit and sheep p38. Detects a band of ~38kDa by Western blot.
Formulation:
Liquid. Whole rabbit serum.
Application Info:
Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:500)
Western Blot (1:10,000, ECL)
Optimal conditions must be determined individually for each application.
Protocol:
Tips Information:

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