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HIF1A Antibody (OABF00275)

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100 ul
$289.00
In Stock

Conjugation Options

OABF00275-FITC Conjugated

OABF00275-HRP Conjugated

OABF00275-Biotin Conjugated

Gene Symbol:
HIF1A
NCBI Gene Id:
3091
Official Gene Full Name:
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Swissprot Id:
Q16665
Alias Symbols:
HIF1, MOP1, PASD8, HIF-1A, bHLHe78, HIF-1alpha, HIF1-ALPHA,
Replacement Item:
This antibody may replace item sc-10790 from Santa Cruz Biotechnology.
Description of Target:
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 4 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP3. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Purified by Protein A.
Application:
WB, IHC-P
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HIF1A.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express HIF1A.
Immunogen:
KLH conjugated synthetic peptide derived from human of human HIF-1 Alpha
Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
Reconstitution and Storage:
Store at -20C for 12 months.
Concentration:
1ug/ul
Datasheets / Downloads:
OABF00275
Conjugation:
Unconjugated
Isotype:
IgG
Application Info:
WB: 1:100 - 1000
IHC-P: : 1:100 - 500
Additional Information:
Subcellular location: Cytoplasm, Nucleus
Protocol:
Tips Information:
 
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