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GSTT1 Protein (OPPA01869)

5ug
$100.00
In Stock
Gene Symbol:
GSTT1
NCBI Gene Id:
2952
Alias Symbols:
Glutathione S-transferase theta-1, GST class-theta-1, Glutathione transferase T1-1, GSTT1, GSTT1 Human, Glutathione S-Transferase Theta-1 Human Recombinant
Description of Target:
Recombinant Human Glutathione S-Transferase Theta-1
Swissprot Id:
P30711
Protein Accession #:
NP_000844.2
Host:
E. Coli
Protein Name:
Glutathione S-transferase theta-1
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express GSTT1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express GSTT1.
Product Format:
The GSTT1 solution contains 20 mM Tris-HCl buffer (pH 8.0) and 10% glycerol. Physical appearance: Sterile Filtered colorless solution.
Purity:
Greater than 95.0% as determined by SDS-PAGE.
Peptide Sequence:
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGL ELYLDLLSQP CRAVYIFAKK NDIPFELRIV DLIKGQHLSD ACAQVNPLKK VPALKDGDFT LTESVAILLY LTRKYKVPDY WYPQDLQARA RVDEYLAWQH TTLRRSCLRA LWHKVMFPVF LGEPVSPQTL AATLAELDVT LQLLEDKFLQ NKAFLTGPHI SLADLVAITE LMHPVGAGCQ VFEGRPKLAT WRQRVEAAVG EDLFQEAHEV ILKAKDFPPA DPTIKQKLMP WVLAMIR.
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Product Introduction: GSTT1 belongs to a superfamily of proteins which catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. GSTT1 is one of the GSTs' four main classes: alpha, mu, pi and theta (which includes GSTT1 and GSTT2). GSTT1 is involved in activation and detoxification reactions and catalyzes the conjugation of industrial chemicals, such as epoxybutane, ethylene oxides, halomethane with glutathione. GSTT1 is found in erythrocytes, at low levels in the liver as well as in Clara and ciliated cells at the alveolar/bronchiolar junction in the lung.The GSTT1 gene is deficient in 38% of the population. The GSTTI enzyme deficiency might influence the individual risk for development of acquired aplastic anemia and acute myeloid leukemia. The presence or absence of the GSTT1 gene is concurrent with GSST1+ (the conjugator) and GSTT1- (the non-conjugator) phenotypes correspondingly. The GSTT1+ phenotype is able to catalyze the glutathione conjugation of dichloromethane. GSTT1-null genotypes are seen as having a higher risk of developing leukoplakia. Germline genetic polymorphism in GSTT1 is linked to breast cancer.
Product Description: GSTT1 Human Recombinant fused with 37 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 277 amino acids (1-240 a.a.) and having a molecular mass of 31.5kDa.The GSTT1 is purified by proprietary chromatographic techniques.
Reconstitution and Storage:
GSTT1 although stable 4C for 4 weeks, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
Datasheets/Manuals:
Printable datasheet for OPPA01869
Protocol:
Tips Information:

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