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GP1BA Antibody (AMM00007)

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100 ul
$249.00
In Stock
Gene Symbol:
GP1BA
NCBI Gene Id:
2811
Official Gene Full Name:
glycoprotein Ib platelet alpha subunit
Protein Name:
platelet glycoprotein Ib alpha chain
Swissprot Id:
P07359
Protein Accession #:
NP_000164.5
Nucleotide Accession #:
NM_000173.6
Alias Symbols:
BSS, GP1B, VWDP, CD42B, GPIbA, BDPLT1, BDPLT3, DBPLT3, GPIbalpha, CD42b-alpha
Replacement Item:
This antibody may replace item sc-114145 from Santa Cruz Biotechnology.
Description of Target:
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.
Host:
Mouse
Clonality:
Monoclonal
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express GP1BA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express GP1BA.
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
Add 100ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Datasheets / Downloads:
Printable datasheet for anti-GP1BA (AMM00007) antibody
 
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