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FOXA2 antibody - middle region (ARP31944_P050)

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100 ul

Regular Price: $289.00

Special Price: $215.00

In Stock

Conjugation Options

ARP31944_P050-FITC Conjugated

ARP31944_P050-HRP Conjugated

ARP31944_P050-Biotin Conjugated

Gene Symbol:
FOXA2
NCBI Gene Id:
3170
Official Gene Full Name:
Forkhead box A2
Protein Name:
Hepatocyte nuclear factor 3-beta
Swissprot Id:
Q9Y261
Protein Accession #:
NP_068556
Nucleotide Accession #:
NM_021784
Alias Symbols:
HNF3B, MGC19807, TCF3B
Replacement Item:
This antibody may replace item sc-101060 from Santa Cruz Biotechnology.
Description of Target:
FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young.This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene. This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene.
Protein Size (# AA):
457
Molecular Weight:
48kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express FOXA2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express FOXA2.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human FOXA2
Species Reactivity:
Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 77%; Rat: 92%
Complete computational species homology data:
Anti-FOXA2 (ARP31944_P050)
Peptide Sequence:
Synthetic peptide located within the following region: ASQAQLGEAAGPASETPAGTESPHSSASPCQEHKRGGLGELKGTPAAALS
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
PPARGC1B; GSC; EN2; OTX2; ONECUT1; NCOA1; TLE1; MIP; HOXA5; LHX1;
Blocking Peptide:
For anti-FOXA2 (ARP31944_P050) antibody is Catalog # AAP31944 (Previous Catalog # AAPP02841)
Datasheets/Manuals:
Printable datasheet for anti-FOXA2 (ARP31944_P050) antibody
Sample Type Confirmation:

FOXA2 is strongly supported by BioGPS gene expression data to be expressed in 721_B, HepG2

Target Reference:
Yang,G., (2008) Blood 111 (1), 392-401
Publications:

Richards, T. J. et al. Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 302, L746-54 (2012). WB, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat 22268124

Menga, A. et al. Insight into mechanism of in vitro insulin secretion increase induced by antipsychotic clozapine: role of FOXA1 and mitochondrial citrate carrier. Eur. Neuropsychopharmacol. 23, 978-87 (2013). WB, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat 22959654

Kallas, A., Pook, M., Trei, A. & Maimets, T. SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate. Stem Cells Int. 2014, 298163 (2014). WB, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat 24707296

 
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