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FGR Antibody - N-terminal region (OAAB17222)

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400ul
$320.00
In Stock
Gene Symbol:
FGR
NCBI Gene Id:
2268
Protein Name:
Tyrosine-protein kinase Fgr
Swissprot Id:
P09769
Protein Accession #:
NP_001036194.1
Alias Symbols:
FGR, SRC2, Tyrosine-protein kinase Fgr, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Proto-oncogene c-Fgr, p55-Fgr, p58-Fgr, p58c-Fgr
Replacement Item:
This antibody may replace item sc-130 from Santa Cruz Biotechnology.
Description of Target:
Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
59479 Da
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB, IHC, IF
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express FGR.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express FGR.
Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets / Downloads:
OAAB17222
Specificity:
This FGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11~40 amino acids from the N-terminal region of human FGR.
Isotype:
Ig
Application Info:
WB 1:100 - 500
IHC 1:50 - 100
IF 1:10 - 50
Additional Information:
Precautions: FGR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK- dependent activation of AKT1 and MAP kinase signaling Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1
:::
Cellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane (By similarity). Mitochondrion intermembrane space (By similarity) Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes wi
Tissue Location: Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes
Protocol:
Tips Information:

Product Protocol: FGR antibody tested with human 293 by western blot (OAAB17222)

Please find the protocol used to generate the western blot data for item (OAAB17222) by going here

Product datasheet link: FGR antibody (OAAB17222)

Western blot analysis of FGR (arrow) using FGR Antibody (N-term) (Cat.# OAAB17222). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGR gene (Lane 2) (Origene Technologies) .

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology's FGR antibody (OAAB17222) has been tested using other cell lysates and tissues. To obtain more data about this antibody, please email us at info@avivasysbio.com

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva's products are guaranteed for the applications and experimental sample types mentioned. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

Product Protocol: FGR antibody tested with human Ramos by western blot (OAAB17222)

Please find the protocol used to generate the western blot data for item (OAAB17222) by going here

Product datasheet link: FGR antibody (OAAB17222)

The anti-FGR Pab (Cat. # OAAB17222) is used in Western blot to detect FGR in Ramos cell lysate.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology's FGR antibody (OAAB17222) has been tested using other cell lysates and tissues. To obtain more data about this antibody, please email us at info@avivasysbio.com

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva's products are guaranteed for the applications and experimental sample types mentioned. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

Product Protocol: FGR antibody tested with human cancer, breast carcinoma, hepatocarcinoma in immunohistochemistry (IHC) (OAAB17222)

Please go here to see the protocol used for Aviva's FGR antibody (OAAB17222)

Product datasheet can be found here: FGR antibody (OAAB17222)

IHC information:
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology's FGR antibody (OAAB17222) has been tested using other cell lysates and tissues. To obtain more data about this antibody, please email us at info@avivasysbio.com

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva's products are guaranteed for the applications and experimental sample types mentioned. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

 
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