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Delta-theraphotoxin-Hm1a Recombinant Protein (Togo starburst baboon spider) (OPCA04656)

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Gene Symbol:
Delta-theraphotoxin-Hm1a
Description of Target:
Gating modifier toxin that principally inhibits inactivation of the mammalian voltage-gated sodium channel Nav1.1/SCN1A. When tested against human Nav1.1/SCN1A-Nav1.8/SCN10A alpha subunits heterologously expressed in Xenopus oocytes, the toxin inhibits inactivation of Nav1.1 (EC(50)=38 nM), with substantially weaker effects on Nav1.2/SCN2A (EC(50)=236 nM) and Nav1.3/SCN3A (EC(50)=220 nM). The toxin inhibits several subtypes of voltage-gated potassium channels with significantly lower potency than its effects on Nav1.1/SCN1A.
Swissprot Id:
P60992
Protein Name:
Delta-theraphotoxin-Hm1a
Molecular Weight:
24 kDa
Product Format:
Liquid
Species Reactivity:
Togo starburst baboon spider
Formulation:
Tris-base, 50% glycerol
Purity:
Greater than 90% as determined by SDS-PAGE.
Protein Sequence:
Full Length: ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS
Storage Buffer:
Tris-base, 50% glycerol
Source:
E.coli
Additional Information:
Species Specificity Detail: Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)
Tag:
N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Reconstitution and Storage:
Store at -20/-80C for 12 months. Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Target Reference:
The genome of Epstein-Barr virus type 2 strain AG876.Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.Virology 350:164-170(2006)
Datasheets/Manuals:
Printable datasheet for OPCA04656
Protocol:
Tips Information:

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