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CYBB Antibody (OALA08883)

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50 uL
$350.00
In Stock
Gene Symbol:
CYBB
NCBI Gene Id:
1536
Official Gene Full Name:
cytochrome b-245, beta polypeptide
Protein Name:
cytochrome b-245 heavy chain
Swissprot Id:
P04839
Protein Accession #:
NP_000388.2
Nucleotide Accession #:
NM_000397.3
Alias Symbols:
CYBB, Chronic granulomatous disease, CGD91-phox, Cytochrome b558 subunit beta, Cytochrome b(558) subunit beta, gp91-1, gp91-PHOX, p22 phagocyte B-cytochrome, AMCBX2, CGD, Cytochrome b-245 heavy chain, gp91PHOX, NADPH oxidase 2, NOX2, p91-PHOX
Replacement Item:
This antibody may replace item sc-130543 from Santa Cruz Biotechnology.
Description of Target:
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Immunoaffinity purified
Application:
IHC-P
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CYBB.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CYBB.
Immunogen:
Synthetic peptide around Ile502 of human GP91PHOX / NOX2
Species Reactivity:
Mouse, Rat, Human
Product Format:
Liquid
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
1 mg/mL
Datasheets / Downloads:
Printable datasheet for anti-CYBB (OALA08883) antibody
Preservative:
0.05% Sodium Azide
Formulation:
PBS, pH 7.2, 0.05% sodium azide
Protocol:
Tips Information:
 
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