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CYBB Antibody (OACA02822)

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100 ug
    In Stock
    Gene Symbol:
    NCBI Gene Id:
    Official Gene Full Name:
    cytochrome b-245 beta chain
    Protein Name:
    Cytochrome b-245 heavy chain
    Swissprot Id:
    Protein Accession #:
    Nucleotide Accession #:
    Alias Symbols:
    CGD, CGD91-phox, Cytochrome b(558) subunit beta, Cytochrome b-245 heavy chain, Cytochrome b558 subunit beta, gp91-1, GP91-1, GP91PHOX, gp91-phox, GP91-PHOX, Heme-binding membrane glycoprotein gp91phox, NADPH oxidase 2, Neutrophil cytochrome b 91 kDa polyp
    Replacement Item:
    This antibody may replace item sc-5826 from Santa Cruz Biotechnology.
    Description of Target:
    Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
    Caprylic Acid Ammonium Sulfate Precipitation purified
    Tissue Tool:
    Find tissues and cell lines supported by DNA array analysis to express CYBB.
    RNA Seq:
    Find tissues and cell lines supported by RNA-seq analysis to express CYBB.
    Recombinant human Cytochrome b-245 heavy chain protein (283-570AA)
    Species Reactivity:
    Product Format:
    Reconstitution and Storage:
    Shipped at 4C. Upon delivery aliquot and store at -20C or -80C. Avoid repeated freeze.
    Datasheets / Downloads:
    Printable datasheet for anti-CYBB (OACA02822) antibody
    0.03% Proclin 300
    50% Glycerol, 0.01M PBS, PH 7.4
    Target Reference:
    [1]"Clinical, functional, and genetic characterization of chronic granulomatous disease in 89 Turkish patients." Koeker M.Y., Camcioglu Y., van Leeuwen K., Kilic S.S., Barlan I., Yilmaz M., Metin A., de Boer M., Avcilar H., Patiroglu T., Yildiran A., Yegin O., Tezcan I., Sanal O., Roos D. J. Allergy Clin. Immunol. 132:1156-1163(2013). [2]"Identification and functional characterization of two novel mutations in the alpha-helical loop (residues 484-503) of CYBB/gp91(phox) resulting in the rare X91(+) variant of chronic granulomatous disease." Boog B., Quach A., Costabile M., Smart J., Quinn P., Singh H., Gold M., Booker G., Choo S., Hii C.S., Ferrante A. Hum. Mutat. 33:471-475(2012). [3]"Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease." Bustamante J., Arias A.A., Vogt G., Picard C., Galicia L.B., Prando C., Grant A.V., Marchal C.C., Hubeau M., Chapgier A., de Beaucoudrey L., Puel A., Feinberg J., Valinetz E., Janniere L., Besse C., Boland A., Brisseau J.M. Casanova J.L. Nat. Immunol. 12:213-221(2011).
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