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CTNNB1 Antibody - N-terminal region (OAGA01590)

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100 ul
$289.00
In Stock
Gene Symbol:
CTNNB1
NCBI Gene Id:
1499
Official Gene Full Name:
catenin (cadherin-associated protein), beta 1, 88kDa
Swissprot Id:
P35222
Alias Symbols:
CTNNB, MRD19, armadillo
Replacement Item:
This antibody may replace item sc-116622, HPA029159
Description of Target:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Purified by antigen-affinity chromatography.
Application:
IF, IHC-P, IP, WB, CHIP
Tissue Tool:
Find tissues and cell lines supported to express CTNNB1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CTNNB1.
Immunogen:
Recombinant protein encompassing a sequence within the N-terminus region of human beta Catenin. The exact sequence is proprietary.
Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Concentration:
1mg/ml
Datasheets / Downloads:
Printable datasheet for anti-CTNNB1 (OAGA01590) antibody
Isotype:
IgG
Application Info:
Suggested starting dilutions are as follows: WB: 1:500-1:3000, IP: 1:100-1:500, IHC-P: 1:100-1:1000, ICC/IF: 1:100-1:1000, IP: 1:100-1:500, ChIP. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
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Protocol:
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