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COPS6 antibody - middle region (ARP59350_P050)

100 ul

Regular Price: $289.00

Special Price: $215.00

In Stock

Conjugation Options

ARP59350_P050-FITC Conjugated

ARP59350_P050-HRP Conjugated

ARP59350_P050-Biotin Conjugated

Gene Symbol:
COPS6
NCBI Gene Id:
10980
Official Gene Full Name:
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
Protein Name:
COP9 signalosome complex subunit 6
Swissprot Id:
Q7L5N1
Protein Accession #:
NP_006824
Nucleotide Accession #:
NM_006833
Alias Symbols:
CSN6, MOV34-34KD
Replacement Item:
This antibody may replace item sc-47965 from Santa Cruz Biotechnology.
Description of Target:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.
Protein Size (# AA):
327
Molecular Weight:
36kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express COPS6.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express COPS6.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human COPS6
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Complete computational species homology data:
Anti-COPS6 (ARP59350_P050)
Peptide Sequence:
Synthetic peptide located within the following region: DHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEV
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
NEDD8; CUL1; UBC; COPS5; GPS1; SUMO1; POP7; COPS7B; COPS7A; CUL4B; USP7; COPS4; FBXO6; FBXW4; IGHV3OR15-7; vpr; TP63; RFWD2; SFN; IRF5; COPS8; COPS2; COPS3; DDB2; DDB1; ERCC8; TOR1AIP2; LRR1; RBX1; VPRBP; LRRC14; CUL2; CUL3; CUL4A; CUL5; TCEB2; TCEB1; SKP
Blocking Peptide:
For anti-COPS6 (ARP59350_P050) antibody is Catalog # AAP59350 (Previous Catalog # AAPP45447)
Datasheets/Manuals:
Printable datasheet for anti-COPS6 (ARP59350_P050) antibody
Sample Type Confirmation:

COPS6 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Subunit:
6
Publications:

Pick, E. et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS One 7, e43980 (2012). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 22956996

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