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CDH1 Antibody (OAGA01285)

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100 ul
$289.00
In Stock
Gene Symbol:
CDH1
NCBI Gene Id:
999
Official Gene Full Name:
cadherin 1, type 1
Swissprot Id:
P12830
Alias Symbols:
UVO, CDHE, ECAD, LCAM, Arc-1, CD324
Replacement Item:
This antibody may replace item sc-1499 from Santa Cruz Biotechnology.
Description of Target:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Purified by antigen-affinity chromatography.
Application:
IF, IHC-P, IP, WB
Tissue Tool:
Find tissues and cell lines supported to express CDH1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CDH1.
Immunogen:
Recombinant protein encompassing a sequence within the center region of human E-Cadherin. The exact sequence is proprietary.
Species Reactivity:
Human
Product Format:
Liquid. 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Concentration:
1mg/ml
Datasheets / Downloads:
Printable datasheet for anti-CDH1 (OAGA01285) antibody
Isotype:
IgG
Application Info:
Suggested starting dilutions are as follows: WB: 1:500-1:3000, IP: 1:100-1:500, IHC-P: 1:100-1:1000 [suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)], ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
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Protocol:
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