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CD13 Antibody - FITC Conjugated (OADB00044)

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1 mL
$265.00
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Gene Symbol:
CD13
NCBI Gene Id:
290
Official Gene Full Name:
alanyl aminopeptidase, membrane
Protein Name:
aminopeptidase N
Swissprot Id:
P15144
Protein Accession #:
NP_001141.2
Nucleotide Accession #:
NM_001150.2
Alias Symbols:
APN, CD13, LAP1, P150, PEPN, GP150
Description of Target:
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.
Molecular Weight:
110 kDa
Host:
Mouse
Clonality:
Monoclonal
Purification:
Ion exchange chromatography
Application:
FC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CD13.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CD13.
Species Reactivity:
Human
Product Format:
Lyophilized
Reconstitution and Storage:
Stable at +2-8C for 12 months. For longer storage, freeze aliquots
Concentration:
100 tests/1mL
Datasheets/Manuals:
Printable datasheet for anti-CD13 (OADB00044) antibody
Preservative:
Sodium Azide
Specificity:
Recognises aminopeptidase N, a 150-170 kDa protein
Formulation:
Phosphate-buffered saline with 5 % BSA and 0.1 % sodium azide
Clone:
B-F10
Conjugation:
FITC
Isotype:
IgG1
Storage Buffer:
Phosphate-buffered saline with 5 % BSA and 0.1 % sodium azide
Target Reference:
Brok, H.P. et al., Cytometry,2001;45(4):294-303
Protocol:
Tips Information:
 
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