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CASP3 Antibody (OAAH00031)

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100 ul
$220.00
In Stock
Gene Symbol:
CASP3
NCBI Gene Id:
836
Official Gene Full Name:
Caspase-3
Protein Name:
Caspase-3
Swissprot Id:
P42574
Protein Accession #:
NP_004337.2; NP_116786.1
Nucleotide Accession #:
NM_004346.3; NM_032991.2
Replacement Item:
This antibody may replace item sc-113427, HPA002643
Description of Target:
This gene is a member of the cysteine-aspartic acid protease (caspase) family. Alternative splicing of this gene results in two transcript variants that encode the same protein. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases-3 exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspases-3 cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10
Protein Size (# AA):
277
Molecular Weight:
32 kDa
Host:
Mouse
Clonality:
Monoclonal
Application:
WB, IF, IHC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CASP3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CASP3.
Immunogen:
This Aviva monoclonal antibody is produced by immunizing mice with recombinant polypeptide (Aviva SEAL mAb technology) corresponding to surface multi-epitopes of human Caspase-3.
Species Reactivity:
Human
Reconstitution and Storage:
Store the product at -20C. Stable for one year from the date of shipment.
Datasheets / Downloads:
Printable datasheet for anti-CASP3 (OAAH00031) antibody
Specificity:
Caspase-3 Mouse monoclonal antibody detects endogenous levels of Caspase-3 protein.
Source:
Mouse mAb
Isotype:
Mouse IgG
Application Info:
WB: 1:500-1:1000
Additional Information:
Localization: Cytoplasm
Target Reference:
1.Benhar, M., Forrester, M. T., Hess, D. T., Science 320: 1050-1054, 2008.
2.Gervais, F. G., Xu, D., Robertson, G. S., Cell 97: 395-406, 1999.
3.Lakhani, S. A., Masud, A., Kuida, K., Science 311: 847-851, 2006.
Protocol:
Tips Information:
 
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