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CASP1 Antibody (OAAB21733)

  • Catalog#: OAAB21733
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100 ul
$320.00
Discontinued
Gene Symbol:
CASP1
NCBI Gene Id:
834
Official Gene Full Name:
caspase 1
Swissprot Id:
P29466
Protein Accession #:
NP_001214.1
Nucleotide Accession #:
NM_001223.4
Alias Symbols:
ICE, P45, IL1BC
Replacement Item:
This antibody may replace item sc-119024 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Molecular Weight:
45 kDa
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB, IF, FC, IHC-P
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CASP1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CASP1.
Species Reactivity:
Human, Mouse
Predicted Homology Based on Immunogen Sequence:
Human, Mouse
Product Format:
Liquid
Reconstitution and Storage:
Store at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets / Downloads:
Printable datasheet for anti-CASP1 (OAAB21733) antibody
Preservative:
0.03% Proclin300 and 50% glycerol
Formulation:
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Additional Information:
Function: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Protocol:
Tips Information:
 
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