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PRKACB Antibody - N-terminal region (Phospho-E32) (OAAB16788)

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400ul
$320.00
In Stock
Gene Symbol:
PRKACB
NCBI Gene Id:
5567
Protein Name:
cAMP-dependent protein kinase catalytic subunit beta
Swissprot Id:
P22694
Protein Accession #:
NP_001229786.1
Alias Symbols:
PRKACB, cAMP-dependent protein kinase catalytic subunit beta
Replacement Item:
This antibody may replace item sc-28315 from Santa Cruz Biotechnology.
Description of Target:
Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
40623 Da
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PRKACB.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PRKACB.
Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB16788
Specificity:
This c-AMPProtein Kinase Catalytic subnunit Antibody antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25~54 amino acids from the N-terminal region of human PRKACB.
Isotype:
Ig
Application Info:
WB 1:100 - 500
Additional Information:
Precautions: c-AMPProtein Kinase Catalytic subnunit Antibody (N-term E32) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis
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Cellular Location: Cytoplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity)
Tissue Location: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain
 
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