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BDNF Antibody - C-terminal region (OAAB05026)

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400ul
$320.00
In Stock
Gene Symbol:
BDNF
NCBI Gene Id:
627
Protein Name:
Brain-derived neurotrophic factor
Swissprot Id:
P23560
Protein Accession #:
NP_001137277.1
Alias Symbols:
Brain-derived neurotrophic factor, BDNF, Abrineurin
Replacement Item:
This antibody may replace item sc-20981 from Santa Cruz Biotechnology.
Description of Target:
BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this protein is reduced in both Alzheimer's and Huntington disease patients. This protein may play a role in the regulation of stress response and in the biology of mood disorders.
Molecular Weight:
27818 Da
Host:
Rabbit
Clonality:
Polyclonal
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Application:
WB, IHC-P, FC, IF
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express BDNF.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express BDNF.
Immunogen:
This BDNF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the C-terminal region of human BDNF.
Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Bovine, Mouse, Pig, Rat
Product Format:
Liquid. PBS with 0.09% (W/V) sodium azide.
Reconstitution and Storage:
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets / Downloads:
Printable datasheet for anti-BDNF antibody - OAAB05026
Isotype:
Ig
Intended Use:
For research use only and not for use in diagnostic or therapeutic procedures.
Application Info:
WB 1:1000
IHC-P 1:10~50
IF 1:10~50
FC 1:10~50
Additional Information:
Function: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Cellular Location: Secreted.
Tissue Location: Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta
Protocol:
Tips Information:

Product Protocol: BDNF antibody tested with human CEM by western blot (OAAB05026)

Please find the protocol used to generate the western blot data for item (OAAB05026) by going here

Product datasheet link: BDNF antibody (OAAB05026)

Western blot analysis of BDNF Antibody (C-term) in CEM cell lysates (35ug/lane). BDNF (arrow) was detected using the purified Pab.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology's BDNF antibody (OAAB05026) has been tested using other cell lysates and tissues. To obtain more data about this antibody, please email us at info@avivasysbio.com

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva's products are guaranteed for the applications and experimental sample types mentioned. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

Product Protocol: BDNF antibody tested with human brain in immunohistochemistry (IHC) (OAAB05026)

Please go here to see the protocol used for Aviva's BDNF antibody (OAAB05026)

Product datasheet can be found here: BDNF antibody (OAAB05026)

IHC information:
Formalin-fixed and paraffin-embedded human brain reacted with BDNF Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology's BDNF antibody (OAAB05026) has been tested using other cell lysates and tissues. To obtain more data about this antibody, please email us at info@avivasysbio.com

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva's products are guaranteed for the applications and experimental sample types mentioned. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

 
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