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BCL2L1 Antibody (Phospho-Ser62) (OASG00744)

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100 uL
$215.00
In Stock
Gene Symbol:
BCL2L1
NCBI Gene Id:
598; 12048; 24888
Official Gene Full Name:
BCL2-like 1
Swissprot Id:
Q07817, Q64373, P53563
Alias Symbols:
BCL2L1, BCL2L, BCLX, Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X
Replacement Item:
This antibody may replace item sc-1041 from Santa Cruz Biotechnology.
Description of Target:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
Molecular Weight:
24 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Application:
WB, IHC, ELISA
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express BCL2L1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express BCL2L1.
Immunogen:
Synthesized peptide derived from human Bcl-x around the phosphorylation site of S62. Location: 40-120aa.
Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Concentration:
1 mg/ml
Datasheets / Downloads:
Printable datasheet for anti-BCL2L1 (OASG00744) antibody
Target Post-Translational Modification:
Phospho-Ser62
Specificity:
Phospho-Bcl-x (S62) Polyclonal Antibody detects endogenous levels of Bcl-x protein only when phosphorylated at S62.
Isotype:
IgG
Application Info:
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Protocol:
Tips Information:
 
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