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BCL2L1 antibody (OAGA00413)

100 ul
$340.00
In Stock
Gene Symbol:
BCL2L1
NCBI Gene Id:
598
Official Gene Full Name:
Bcl-2-like protein 1
Protein Name:
Bcl-2-like protein 1
Swissprot Id:
Q07817
Protein Accession #:
NP_001182.1
Alias Symbols:
BCL-XL/S antibody, BCL2L antibody, BCLX antibody, BCLXL antibody, BCLXS antibody, Bcl-X antibody, DKFZp781P2092 antibody, bcl-xL antibody, bcl-xS antibody, BCL2L1 antibody, apoptosis regulator Bcl-X antibody, bcl-2-like protein 1 antibody, protein phospha
Replacement Item:
This antibody may replace item sc-1041 from Santa Cruz Biotechnology.
Molecular Weight:
26 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Purified by antigen-affinity chromatography.
Application:
ICC, IF, IHC-FFPE, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express BCL2L1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express BCL2L1.
Immunogen:
Recombinant fragment corresponding to a region within amino acids 1 and 208 of Bcl-X (Uniprot ID#Q07817)
Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Concentration:
0.95 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-BCL2L1 antibody - OAGA00413
Isotype:
IgG
Application Info:
Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-P: 1:100-1:1000 [suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)], ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Additional Information:
Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq]
:::
Positive Controls: HCT116, NIH-3T3, PC-12
:::
Cellular Localization: Mitochondrion membrane; Single-pass membrane protein, Nucleus membrane; Single-pass membrane protein; Cytoplasmic side, Mitochondrion membrane, Nucleus membrane
Storage Buffer:
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Protocol:
Tips Information:

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