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Now Offering Over 102,157 Antibodies & 44,722 Antigens!

Anti-FAK Antibody (Phospho-Tyr 576) (OAAI00392)

100 ug
$275.00
In Stock
Gene Symbol:
Ptk2
NCBI Gene Id:
25614
Official Gene Full Name:
protein tyrosine kinase 2
Swissprot Id:
O35346
Alias Symbols:
FAK, FRNK, p125FAK,
Replacement Item:
This antibody may replace item sc-1688 from Santa Cruz Biotechnology.
Description of Target:
Focal adhesion kinase (FAK) gene encodes a cytoplasmic protein tyrosine kinase which is found concentRated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinase but lacks significant sequence similarity to kinase from other subfamilies. Activation by phosphorylation of Y397, Y576/577 and Y863 of FAK protein may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Increased FAK expression has been correlated with the enhanced motility and invasiveness of Human tumor cells, as well as with promoting increased cell prolifeRation
Molecular Weight:
125 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Application:
ELISA, WB, IP
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express Ptk2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express Ptk2.
Immunogen:
A synthetic peptide surrounding to the epitope -STYYKA- with a phosphorylation site at Tyrosine 576 of Human FAK protein. This sequence is identical among Human, Mouse and Rat.
Species Reactivity:
Human
Reconstitution and Storage:
The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity.
Avoid repeated freezing thawing cycles.
Datasheets/Manuals:
Printable datasheet for Rabbit Anti-FAK Antibody (Phospho-Tyr 576) OAAI00392
Specificity:
This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
Isotype:
Rabbit IgG
Application Info:
Positive Control: Conditioned 3T3 Cell Lysate
Western Blot: 0.1-1 μg/ml
ELISA: 0.01-0.1 μg/ml
IP: 2-5 μg/ml
IHC: 1:100
Target Reference:
Leu TH, et al. Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397. Oncogene. 2002 Oct 10;21(46):6992-7000.
Protocol:
Tips Information:

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