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Anti-CD25 Polyclonal Antibody (OAAI00113)

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100 ug
$300.00
In Stock
Gene Symbol:
IL2RA
NCBI Gene Id:
3559
Official Gene Full Name:
interleukin 2 receptor, alpha
Swissprot Id:
P01589
Alias Symbols:
CD25, IL2R, TCGFR, IDDM10,
Replacement Item:
This antibody may replace item sc-13946 from Santa Cruz Biotechnology.
Description of Target:
The IL2 receptor (IL2R) exists in three alternative forms made up from the individual components of CD25, CD122, and CD132. CD25 represents the low affinity alpha chain of the IL2R, a type I transmembrane glycoprotein containing two CCP domains. It is rich in O linked carbohydRates and has a short cytoplasmic tail. CD25 is expressed on activated T cells, B cells, NK cells and monocytes of all Mouse strains tested. It is transiently expressed at a low level during B cell development in bone marrow on the CD45R/B220 low TdT- sIg- pre-B II and CD45R/B220low TdT- sIgM+sIgD- immature B cells, but not on the CD45R/B220 low TdT+ sIg- pro-B/pre B I stage nor on CD45R/B220high TdT- sIgM+sIgD+ mature B cells. CD25 is expressed at a higher level during very early T cell development in fetal and adult thymus. CD25 expression is a common denominator of a specific immunomodulatory B-cell subset ready to prolifeRate upon IL-2 stimulation.
Molecular Weight:
31 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
The rabbit polyclonal Antibody is purified by affinity purification.
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express IL2RA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express IL2RA.
Immunogen:
Recombinant full length (1-272 aa) of Human CD25.
Species Reactivity:
Human
Reconstitution and Storage:
The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity.
Avoid repeated freezing thawing cycles.
Datasheets/Manuals:
Printable datasheet for Rabbit Anti-CD25 Polyclonal AntibodyOAAI00113
Specificity:
This antibody reacts with Human. The other species are not tested.
Isotype:
Rabbit IgG
Application Info:
Positive Control: Jurkat Cells. Tonsil
Western Blot: 0.1-1 μg/ml
ELISA: Not tested
IP: 2-5 μg/ml
IHC: Not tested
Target Reference:
Amu,S. and Brisslert,M. Phenotype and function of CD25-expressing B lymphocytes isolated from Human umbilical cord blood. Clin. Dev. Immunol. 2011, 481948 (2011).
Protocol:
Tips Information:
 
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