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AMFR Antibody - N-terminal region (ARP88922_P050)

100 ul
$289.00
In Stock
Gene Symbol:
AMFR
NCBI Gene Id:
23802
Official Gene Full Name:
autocrine motility factor receptor
Protein Name:
E3 ubiquitin-protein ligase AMFR
Swissprot Id:
Q9R049
Protein Accession #:
NP_035917.2
Nucleotide Accession #:
NM_011787.2
Alias Symbols:
gp78
Description of Target:
E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis (By similarity).
Protein Size (# AA):
643
Molecular Weight:
70 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express AMFR.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express AMFR.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of mouse AMFR
Species Reactivity:
Mouse
Peptide Sequence:
Synthetic peptide located within the following region: AYRALSQPEDGSGEPEPLTAPLQPEALAPARLTAGGPRARDVAQYLLSDS
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide:
For anti-AMFR (ARP88922_P050) antibody is Catalog # AAP88922
Datasheets/Manuals:
Printable datasheet for anti-AMFR (ARP88922_P050) antibody

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