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AGER Antibody - FITC Conjugated (OACA01949)

100 ug
$299.00
In Stock
Gene Symbol:
AGER
NCBI Gene Id:
177
Protein Name:
Advanced glycosylation end product-specific receptor
Swissprot Id:
A2BFI7
Alias Symbols:
RAGE,
Replacement Item:
This antibody may replace item sc-170841 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein G purified
Application:
WB, ELISA, IHC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express AGER.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express AGER.
Species Reactivity:
Human
Product Format:
Liquid 0.01M PBS (pH 7.4) with 0.03% Proclin300 and 50% glycerol
Reconstitution and Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Concentration:
Varies by lot. See vial for exact concentration.
Datasheets/Manuals:
Printable datasheet for Rabbit anti-human Advanced glycosylation end product-specific receptor (OACA01949)OACA01949
Conjugation:
FITC-conjugated
Purity:
>95%
Isotype:
IgG
Target Reference:
[1] Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.'Neeper M., Schmidt A.M., Brett J., Yan S.D., Wang F., Pan Y.C., Elliston K., Stern D., Shaw A.J. Biol. Chem. 267:14998-15004(1992)
[2] Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.'Sugaya K., Fukagawa T., Matsumoto K., Mita K., Takahashi E., Ando A., Inoko H., Ikemura T.Genomics 23:408-419(1994)
[3] Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.'Yonekura H., Yamamoto Y., Sakurai S., Petrova R.G., Abedin J., Li H., Yasui K., Takeuchi M., Makita Z., Takasawa S., Okamoto H., Watanabe T., Yamamoto H.Biochem. J. 370:1097-1109(2003)
Protocol:
Tips Information:

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