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4 1BBL Protein (OPPA01890)

5ug
$100.00
In Stock
Gene Symbol:
4 1BBL
NCBI Gene Id:
8744
Alias Symbols:
CD137L, CD137-L, 4-1BBL, 4-1BB Ligand, TNFSF9, Tumor Necrosis Factor (ligand) Superfamily Member 9, 4 1BBL Human, 4-1BB Ligand Human Recombinant
Description of Target:
Recombinant Human 4-1BB Ligand
Swissprot Id:
P41273
Protein Accession #:
NP_003802.1
Host:
E. Coli
Protein Name:
Tumor necrosis factor ligand superfamily member 9
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express 4 1BBL.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express 4 1BBL.
Product Format:
Recombinant 4-1BBL contains 20mM Tris buffer pH-8, 100mM NaCl and 20% glycerol. Physical appearance: Sterile Filtered colorless solution.
Purity:
Greater than 95.0% as determined by SDS-PAGE
Peptide Sequence:
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTGGLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL GVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE.
:::
Product Introduction: 4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor (TNF) ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin
Product Description: TNFSF9 Human Recombinant fused to 37 amino acids His tag at N-terminus produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids (71-254 a.a.) and having a molecular mass of 23.8 kDa. The TNFSF9 His tag fusion protein is purified by proprietary chromatographic techniques.
Reconstitution and Storage:
4-1BBL although stable at 10C for 3 weeks, should be stored desiccated below -18C. Please prevent freeze-thaw cycles.
Datasheets/Manuals:
Printable datasheet for OPPA01890
Protocol:
Tips Information:

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