ELOA Antibody - C-terminal region (P100692_T100)

Catalog No: P100692_T100

WB Suggested Anti-TCEB3 Antibody Titration: 7.5ug/ml
Positive Control: Transfected 293TTCEB3 is strongly supported by BioGPS gene expression data to be expressed in Human HEK293T cells

Human Pancrease

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Rat, Dog, Guinea Pig
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TCEB3
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Dog: 100%; Guinea Pig: 91%; Rat: 92%
• Peptide Sequence: Synthetic peptide located within the following region: AYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKIAPMMAKTIKAFKNRFSRR
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-ELOA (P100692_T100) antibody is Catalog # AAP31037 (Previous Catalog # AAPP01770)
• Sample Type Confirmation:

  TCEB3 is strongly supported by BioGPS gene expression data to be expressed in HEK293T

Target Info

• Reference: Beausoleil,S.A., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135
• Gene Symbol: ELOA
• Gene Full Name: elongin A
• Alias Symbols: SIII, TCEB3, TCEB3A, SIII p110
• NCBI Gene Id: 6924
• Protein Name: elongin-A
• Description of Target: This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
• Uniprot ID: Q14241
• Protein Accession #: NP_003189
• Nucleotide Accession #: NM_003198
• Protein Size (# AA): 772
• Molecular Weight: 87kDa
• Protein Interactions: KRTAP10-3; CEP57L1; SPERT; FAM9B; KRT40; CEP70; GMCL1; HOMEZ; TRIM54; MID2; PLK4; JAKMIP2; PSMB9; POLR2L; POLR2K; POLR2J; POLR2I; POLR2H; POLR2G; POLR2F; POLR2E; POLR2D; POLR2C; POLR2B; POLR2A; MDFI; UBC; RAD54B; MED26; ECT2; BARD1; CDK12; TCEB2; TCEB1; B