ELL Antibody - C-terminal region : Biotin (ARP30105_T100-Biotin)

Catalog No: ARP30105_T100-Biotin

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Biotin
• Application: IHC, WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ELL
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 86%; Rat: 93%; Zebrafish: 86%
• Peptide Sequence: Synthetic peptide located within the following region: TQLDAQLRQLSQGSEEYETTRGQILQEYRKIKKTNTNYSQEKHRCEYLHS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ELL (ARP30105_T100-Biotin) antibody is Catalog # AAP30105 (Previous Catalog # AAPH00281)
• Reference: Wiederschain,D., (2003) Mol. Cell. Biol. 23 (12), 4230-4246

Target Info

• Gene Symbol: ELL
• Gene Full Name: Elongation factor RNA polymerase II
• Alias Symbols: MEN, ELL1, PPP1R68, C19orf17
• NCBI Gene Id: 8178
• Protein Name: RNA polymerase II elongation factor ELL
• Description of Target: ELL was shown to encode a previously uncharacterized elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. Functionally, ELL resembles Elongin (SIII), a transcription elongation factor regulated by the product of the von Hippel-Lindau (VHL) tumor suppressor gene.
• Uniprot ID: P55199
• Protein Accession #: NP_006523
• Nucleotide Accession #: NM_006532
• Protein Size (# AA): 621
• Molecular Weight: 68kDa
• Protein Interactions: UBC; LOC100363176; SNF8; MCM2; Polr2e; Polr2l; Polr2h; Polr2d; Polr2a; Polr2c; Polr2i; Polr2b; Polr2j; Polr2g; Polr2f; EAF1; ICE2; AFF4; PPP1CA; ICE1; MED26; MLLT3; CDK9; TFPT; KMT2A; MLLT1; USPL1; EAF2; HNRNPU; TP53; ZHX1; SIRT2;